In 1989, gym manager Louise "Lou" Langston meets and falls in love with a young woman, Jaqueline "Jackie" Cleaver, who is a bodybuilder working out at her gym. Jackie, unbeknownst to Lou, has just gotten a job at a shooting range owned by Lou's estranged father, Lou Sr., after having sex with Lou's brother-in-law J.J. Jackie herself is a vagrant, passing through town on her way to a bodybuilding competition in Las Vegas. Lou offers her steroids, which Jackie initially hesitates but ends up using. The two soon have sex and Jackie asks to stay at Lou's apartment.
The pair have dinner with J.J. and Beth, Lou's sister, who does not fully realize his abusive actions. Lou defends Beth and threatens J.J. In return, J.J. tells Lou that he had sex with Jackie, which angers her. While driving home, Lou forces Jackie out of the car, mentioning she wants J.J. dead, but hurriedly lets her back in when two FBI agents arrive. The next day, at a hospital, Lou visits Beth, who has been admitted after J.J. had battered her; Lou Sr. arrives and promises to care for Beth. Jackie, emotionally unstable from spontaneous substance abuse, breaks into J.J.'s home and brutally beats him to death.
A distressed Lou arrives at the scene, admitting she did not actually want J.J. dead. The two drive his corpse and car into a ravine, where Lou formerly helped her father kill his business rivals and dispose of their bodies. On the way there, Lou's friend Daisy, who is infatuated with her, spots them and makes note of Jackie driving Lou's truck. Lou cleans up evidence of the murder while Jackie continues her steroid addiction, growing more agitated. Following an argument, Jackie wounds Lou, then leaves and hitchhikes to Las Vegas. During the competition, Jackie hallucinates vomiting a fully grown Lou due to steroid-induced psychosis and contestants commenting on her weight. In reality, Jackie has vomited on the floor; in her psychosis, she assaults another contestant, which lands Jackie in jail.
Meanwhile, armed with full knowledge of J.J.'s murder, Daisy blackmails Lou into a relationship with her. Lou Sr. bails out Jackie and coerces her to kill Daisy, the sole witness to the murder, with a suppressed pistol. Lou and Daisy are just arriving at her apartment when Jackie shoots Daisy from behind. In a state of panic, Jackie returns to Lou Sr., only to be knocked unconscious. He tells Lou that he has arranged for Jackie to go to prison for double homicide, but she threatens to expose his operation if Lou Sr. does so, causing him to hang up in a rage.
As Lou is cleaning up Daisy's body, she is attacked by a figure whom she manages to fatally shoot, revealing the figure as a police officer on Lou Sr.'s payroll. Realizing her father aims to kill her, Lou bludgeons the officer with a gun and makes her way to his manor, where she encounters Beth who has learned about Lou's involvement with J.J.'s death. Beth denounces Lou, who accepts it before forcing Jackie's location from her. She frees Jackie and tells her to run, before being shot in the leg by Lou Sr. He reveals to Lou that her mother is not dead, but left due to their actions; Lou Sr. for his criminal business and Lou for helping him. Jackie arrives, having grown to gigantic size, and pins down Lou Sr. Lou shoves a gun into his mouth, but relents and leaves him for the police.
Lou and Jackie drive off, stopping the next morning when Lou realizes that Daisy is still alive in the truck bed despite her near-fatal wound; she nonchalantly strangles Daisy to death and dumps her body in a nearby field while Jackie sleeps.
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